Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine Pityriasis rosea (PR) is an acute papulosquamous cutaneous disorder that classically presents with a herald patch rapidly followed by a widespread rash along skin cleavage lines. eCollection 2022. Federal government websites often end in .gov or .mil. Before Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. See this image and copyright information in PMC. Is there a prescription cream or ointment that you can prescribe? Accessibility (a) Patient 1: Thin red to tan oval plaques with peripheral scale on the trunk. Coronavirus: Five skin conditions linked to COVID-19 after - 9News Would you like email updates of new search results? McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. Pityriasis rosea Gibert type rash in an asymptomatic patient that tested positive for COVID-19. 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. Nevertheless, she did not present with fever or respiratory tract symptoms. Disclaimer. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. J Eur Acad Dermatol Venereol 2020;34:e4367. eCollection 2022 Jul. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Cutis. She diagnosed it as pityriasis rosea, a benign but frustratingly itchy rash that in her words just happens sometimes. Accessibility Zendaya Shows Off Her Short Sunshine Curls. 8600 Rockville Pike Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. doi: 10.1111/dth.15601. *Correspondence: Poonkiat Suchonwanit, [email protected], ORCID: Kanchana Leerunyakul orcid.org/0000-0002-0669-5611Kallapan Pakornphadungsit orcid.org/0000-0003-4783-0282Poonkiat Suchonwanit orcid.org/0000-0001-9723-0563, COVID-19 Associated Cutaneous Manifestations and COVID-19 Vaccine Related Skin Reactions, View all
2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. 2022 May;11(2):222-225. doi: 10.7774/cevr.2022.11.2.222. J Med Virol. Dos Santos PG, Vieira HCVS, Wietholter V, Gallina JP, Andrade TR, Marinowic DR, Zanirati GG, da Costa JC. Int J Infect Dis. Your healthcare provider can typically diagnose pityriasis rosea after a physical exam. Clinical findings of pityriasis rosealike, Clinical findings of pityriasis rosealike eruption in the patients. I put on some hydrocortisone and went to sleep, then woke up with another mark on my side, a couple inches below my armpit. 2021 Nov 2;17(11):4097-4098. doi: 10.1080/21645515.2021.1963173. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. Though there's no single-known cause, it may be brought on by a drug interaction, or the reactivation of herpes simplex virus 6 or 7. "It looks very different.". J Formos Med Assoc. Pityriasis rosea doesnt usually affect people over the age of 60. The available COVID-19 vaccines entail different levels of risk for skin reactions. doi: 10.1111/bjd.20143. The patient had a positive RT-PCR result, and was confirmed with SARS-CoV-2 infection. The site is secure. In: Papadakis MA, McPhee SJ, Bernstein J., eds. Lessons: Most people with the rash are 10 to 35 years of age. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). Allure may earn a portion of sales from products that are purchased through our site as part of our Affiliate Partnerships with We present two cases of COVID-19 vaccine-induced pityriasis rosea. 2021 Jul;85(1):46-55. doi: 10.1016/j.jaad.2021.03.092. Federal government websites often end in .gov or .mil. J Eur Acad Dermatol Venereol. Bethesda, MD 20894, Web Policies (d) Patient 2: Closeup of plaques, with the hyperpigmented centre and trailing scale. Various mild and benign cutaneous manifestations of the different forms of the COVID-19 vaccine have been documented. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. The clinics of HHV-6 infection in COVID-19 pandemic: Pityriasis rosea and Kawasaki disease. (No.) Nevertheless, the incidence of skin reactions after mRNA vaccinations was low. It's also what's known as a self-limiting rash, Hartman says, in that it can resolve itself on its own without treatment in about six to eight weeks. Bethesda, MD 20894, Web Policies Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. Refined carbohydrates, such as sugar, pastries and white bread. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Pityriasis rosea - Diagnosis and treatment - Mayo Clinic 2021 Aug;185(2):e34. Yes, There Is a Correct Order for Everything You Do in the Shower, Each Zodiac Sign's Unique Personality Traits, Swoopy 1960s Hair Was Everywhere at the SAG Awards, Christina Aguilera Opened Up About Getting Injections and Why She Doesn't Care If People Judge Her, "I think we all can rely on a little help. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. Fortunately, PR-like eruption is responsive to topical corticosteroids without any systemic adverse effects. We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. All rights reserved. Disseminated erythematous-papulosquamous lesions, with right laterocervical herald patch (clinical aspect on admission). Hum Vaccin Immunother. Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. We present the case of a female patient in whom the diagnosis of pityriasis rosea led to the investigation and diagnosis of the SARS-CoV-2 infection. It looked like one, and it certainly itched like one but then more came. No use, distribution or reproduction is permitted which does not comply with these terms. Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine eCollection 2022. If you have pityriasis rosea, you dont have to avoid any foods or drinks. Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . FOIA HHS Vulnerability Disclosure, Help Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. -, Mahajan K, Relhan V, Relhan AK, et al. Cleveland Clinic is a non-profit academic medical center. doi: 10.1016/j.jaad.2020.04.094, 8. Clipboard, Search History, and several other advanced features are temporarily unavailable. NCI CPTC Antibody Characterization Program, Ehsani AH, Nasimi M, Bigdelo Z. Pytiriasis rosea as a cutaneous manifestation of COVID-19 infection. N Engl J Med 2020; 383: 2603-2615. Vaccinations have been identified to rarely cause several cutaneous reactions. It said blood spots under the skin might also be present, either as spots or dots or on larger areas. eCollection 2021. National Library of Medicine Though pityriasis rosea is a common skin rash, it can still make you feel self-conscious, and it can be unpleasant if it itches. Pityriasis Rosea Induced by COVID-19 Vaccination Eur J Case Rep Intern Med. Factors affecting the severity of central centrifugal cicatricial alopecia. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. You may be more likely to develop it if youre: In some cases, people with pityriasis rosea report that they had significant or long-term stress before developing a rash. Drago F, Ciccarese G, Rebora A, Parodi A. The site is secure. doi: 10.1111/dth.13650, 7. This site needs JavaScript to work properly. N Engl J Med 2020; 383: 26032615. Pityriasis rosea: An update on etiopathogenesis and management of difficult aspects. Among patients who received inactivated vaccines, another case of PR-like eruption was reported four days after the first dose of CoronaVac (SinoVac) (1). Pityriasis rosea developing after COVID-19 vaccination. Atzori L, Pinna AL, Ferreli C, Aste N. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. However, if you experience any symptoms, therapy can provide relief. 2022 Aug 11;9(8):43. doi: 10.3390/medicines9080043. 2021 Sep 7;8:752443. doi: 10.3389/fmed.2021.752443. Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review. Ciccarese G, Parodi A, Drago F. SARS-CoV-2 as possible inducer of viral reactivations. Published by Wolters Kluwer Health, Inc. Your Random Rash Could Be Pityriasis Rosea - Yahoo! Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Hardin J. Pityriasis Rosea. eCollection 2022. An official website of the United States government. Disclaimer. J Invest Dermatol. Epub 2022 Jun 21. As King notes, there have been some reported cases of pityriasis rosea occurring in patients after receiving certain vaccines, like the flu shot. HHS Vulnerability Disclosure, Help and transmitted securely. (2020) 83:e5760. However, a fungus causes ringworm. 7 Articles, This article is part of the Research Topic, Creative Commons Attribution License (CC BY), Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection. Suchonwanit P, Hector CE, Bin Saif GA, McMichael AJ. official website and that any information you provide is encrypted One case of pityriasis rosea is reported in a patient infected with COVID-19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. doi: 10.1111/bjd.20143. At home, she underwent systemic treatment with antihistamines and topical medication with dermatocorticosteroids. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. sharing sensitive information, make sure youre on a federal From grooming sets to self-care gadgets, we've got them covered. The https:// ensures that you are connecting to the Epub 2022 Jun 26. Unable to load your collection due to an error, Unable to load your delegates due to an error. Foods that have anti-inflammatory properties include: Foods that may increase inflammation include: There isnt any way to prevent pityriasis rosea. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. One case of pityriasis rosea is reported in a patient infected with COVID19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. Curr Dermatol Rep. 2022;11(4):289-312. doi: 10.1007/s13671-022-00370-9. However, there isnt enough research to determine that stress may cause pityriasis rosea. For most people, it resolves without treatment. In addition to a corticosteroid cream, New York City-based dermatologist Macrene Alexiades recommends keeping showers short and lukewarm, as "water, sweat, and soap reportedly irritate and inflame the lesions. doi: 10.1111/j.0022-202X.2005.23719.x. doi: 10.1159/000517971. National Library of Medicine Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. J Eur Acad Dermatol Venereol 2016; 30: 544545. doi: 10.1111/jdv.17301. Dermatologic side effects of COVID-19 vaccines range from morbilliform rash and pernio to pityriasis rosea and erythema multiforme. Clipboard, Search History, and several other advanced features are temporarily unavailable. Drago F, Ciccarese G, Javor S, et al. The authors of one 2014 case report of a 71-year-old man who suffered from pityriasis rosea one month after receiving an influenza vaccine concluded that "altered immunity" could result in reactivation of HHV-6 and/or HHV-7 which may have triggered an atypical presentation of PR. The authors suggest more research is necessary. Few scattered dyskeratotic keratinocytes are seen in the lower epidermis. Appointments 216.444.5725 Appointments & Locations Request an Appointment Policy. Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. Alamri A, Alghamdi Y, Alamri SJ, Althaqafi MK, AlQurashi W, Bader BA, Mohanna AT, Almahdi B. Cureus. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Pityriasis rosea: Diagnosis and treatment - American Academy of Dermatology World J Clin Cases. How can you tell that I have pityriasis rosea? | Pityriasis Rosea, COVID-19 and . Careers. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. It was described as "clinically reminiscent" of pityriasis rosea by the authors, from the divisions of dermatology and venereology, pathology, intensive care, and the virology laboratory, of the Hpital Cochin, Paris. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Our reported case adds to the other findings regarding the association of PR with SARS-CoV-2 infection, in the context of the pandemic, suggesting the need to test patients with PR skin lesions for SARS-CoV-2 infection. and transmitted securely. Patient concerns: We present the case of a female patient in whom the diagnosis of pityriasis rosea led to the investigation and diagnosis of the SARS-CoV-2 infection. The papillary dermis shows melanin incontinence, perivascular lymphocytic infiltrate and rare scattered extravasated red blood cells. 2021;35(8):e489e491. PR is a common self-limited papulosquamous eruption typically presenting with a large solitary pink-colored patch or plaque (i.e., herald patch), followed by secondary eruptions of smaller erythematous patches or plaques with associated peripheral collarette scaling distributed along the cleavage lines of the trunk, forming a Christmas tree pattern (5). doi: 10.1111/dth.13878, 10. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. How quickly did it come on, and did my boyfriend also have it? You may develop a raised, discolored, circular or oval-shaped patch that ranges from 1 to 6 centimeters (cm). Adverse cutaneous reactions following COVID-19 vaccines have increased, highlighting not only how SARS-CoV-2 infection but also COVID-19 vaccines may induce adverse cutaneous manifestations. The mechanisms behind these COVID-19-related symptoms remain unclear. In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. Int J Infect Dis. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Bethesda, MD 20894, Web Policies Those ensuing spots like the circle of dots that erupted on my back a day after the initial raised welt appeared typically resemble a Christmas tree-like formation. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. Pityriasis rosea-like eruption revealing COVID-19. The site is secure. Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. This site needs JavaScript to work properly. Rashes should be considered a "key diagnostic sign" of Covid-19, according to a study, which found 8% of people who test positive for the virus have some form of rash. Learning points: Cureus. Epub 2022 Feb 9. PMC Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. These findings were consistent with a diagnosis of PR-like eruption. Rare Heterogeneous Adverse Events Associated with mRNA-Based COVID-19 Vaccines: A Systematic Review. And the itch usually only lasts for a few days mine finally let up around day seven but the rash can leave behind dark marks that eventually resolve on their own, Lam says. Keywords: For instance, the rash sometimes appears only under the arms or on the flanks. Histopathological Patterns of Cutaneous Adverse Reaction to Anti-SARS-CoV-2 Vaccines: The Integrative Role of Skin Biopsy. The herald patch is the telltale sign that your rash could be PR, but there are other common (though not universal) symptoms as well. Figure 2. Pityriasis rosea developing after COVID19 vaccination Clinical aspect of the lesions after 7 days of treatment. The Covid Symptom Study. Once its gone, you likely wont develop it again. Medicine (Baltimore). 2022 Feb 20;14(2):e22414. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. Frontiers | Case Report: Pityriasis Rosea-Like Eruption Following COVID Numerous scattered erythematous plaques with fine scale oriented along skin cleavage, Herald patch of pityriasis rosea. COVID-19 Skin Manifestation Heterogeneity - MedicineNet Pityriasis Rosea Induced by COVID-19 Vaccination - PubMed Healthcare experts believe herpesvirus 6 (HHV-6), HHV-7 and/or HHV-8 cause pityriasis rosea, but there arent any conclusive studies. -, Neoh CY, Tan AW, Mohamed K, et al. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. 2020 Sep 25;155(6):273. doi: 10.1016/j.medcli.2020.05.024. We do not endorse non-Cleveland Clinic products or services. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. Med Clin (Barc). J Eur Acad Dermatol Venereol. Birlutiu V, Dobritoiu ES, Lupu CD, Herteliu C, Birlutiu RM, Dragomirescu D, Vorovenci A. -, Busto-Leis J.M., Servera-Negre G., Mayor-Ibarguren A., et al. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. The study said the appearance was similar to pityriasis rosea, a common skin condition. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. The transformation will take your breath away. Atypical pityriasis rosea associated with mRNA COVID19 vaccine Outcome: Clipboard, Search History, and several other advanced features are temporarily unavailable. See your skin clear. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage lines, most appreciable on the upper portion of the chest. JAAD Case Rep. (2018) 4:8001. PMC If you have pityriasis rosea, it can generally be well-managed without any treatment. While you don't need to treat the rash, some patients ask for treatment to take care of the following. Cutis. 2022 Aug;35(8):e15601. Anyone can get pityriasis rosea. User Agreement and Privacy Policy and Cookie Statement and